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  • Myocardial Infarction

    A heart attack (myocardial infarction) is usually caused by a blood clot, which stops the blood flowing to a part of your heart muscle.

    What is Myocardial Infarction


    Myocardial infarction, commonly known as a heart attack, is the irreversible necrosis of heart muscle secondary to prolonged ischemia. This usually results from an imbalance in oxygen supply and demand, which is most often caused by plaque rupture with thrombus formation in a coronary vessel, resulting in an acute reduction of blood supply to a portion of the myocardium or muscles death. The risk factors for atherosclerosis and heart attack include elevated cholesterol levels, increased blood pressure, tobacco use, diabetes, male gender, and a family history of heart attacks at an early age.

    Types of Myocardial Infarction (MI) : - MI is of five types follows as : -

    Type 1 - Type 1 is a spontaneous MI related to ischemia from a primary coronary event (e.g., plaque rupture, thrombotic occlusion)
    Type 2 - Myocardial infarction secondary to ischaemia due to either increased oxygen demand or decreased supply, e.g. coronary artery spasm, coronary embolism, anaemia, arrhythmias, hypertension, or hypotension.
    Type 3 - Sudden unexpected cardiac death, including cardiac arrest
    Type 4 - Associated with coronary angioplasty or stents.
    Type 4a - Myocardial infarction associated with PCI
    Type 4b - Myocardial infarction associated with stent thrombosis as documented by angiography or at autopsy.
    Type 5 - Myocardial infarction associated with CABG .

    Don't worry. We are here to help you to recover soon.

    Introduction:


    Currently available surgical or endovascular revascularization like angioplasty and coronary artery bypass graft (CABG) and drug based method are available treatment for Myocardial Infarction and coronary arterial disease.

    But the stem cells transplant with angioplasty and CABG induces neo-myogenesis and neo-vascularization. Because neo-myogenesis or muscle regeneration is very difficult task in heart attack patient by its self even after angioplasty and CABG. In case of angioplasty, stem cell transplantation performs into the infarct-related coronary artery and induces both new blood formation and muscle regeneration and also decrease the further chance of heart attack.But in case of bypass surgery (or CABG), stem cell transplantation perform into the transplanted artery and directly into the infracted myocardium and induce new muscles regeneration and also decrease the further chance of heart attack.


    A heart attack (myocardial infarction) is usually caused by a blood clot, which stops the blood flowing to a part of your heart muscle.

    Scientific Papers


    1. Strauer et al. 2010 (European Journal of Heart Failure). The acute and long-term effects of intracoronary Stem cell Transplantation in 191 patients with chronic heary failure: the STAR-heart study.
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