Peripheral arterial disease (PAD) is a disease in which plaque builds up in the arteries that carry blood to your head, organs, and limbs. Plaque is made up of fat, cholesterol, calcium, fibrous tissue, and other substances in the blood. Over time, plaque can harden and narrow the arteries. This limits the flow of oxygen-rich blood to your organs and other parts of your body.
Peripheral arterial disease (PAD), causing an inadequate oxygen supply to the limbs. Mainly the risk factors of peripheral vascular disease are nicotine use, diabetes mellitus, hypertension and hypercholesterolemia. Based on the severity of the symptoms, usually two clinical presentations are distinguished: intermittent claudication (IC) is characterized by pain upon walking which is the most common presenting symptom while critical limb ischemia (CLI) is a more severe form in which pain occurs at rest and which is accompanied by necrosis and ulceration and patients with CLI are also at high risk for limb amputation.