Chronic Kidney Disease (CKD) is a medical condition in which the kidney gradually loses its functions and ultimately stops working. It is a disease that affects many people. Kidneys are the vital organs that are anatomically made from nephrons. These tiny structures work as the key regulator for maintaining the proper functioning of the kidneys. They filter the blood, maintain the salt levels, and flush out the toxins through urine.
Any damage to these nephrons leads to CKD. In this disease, the kidneys become dysfunctional for more than 3 months. It is asymptomatic and fatal. Stem cell therapy in India can be a ray of hope for these patients.
The Symptoms of Chronic Kidney Disease:
The symptoms of this disease appear weeks, months, or years after it starts developing inside the body. Some signs are obvious while most of the symptoms go unnoticed. The common symptoms of CKD include:
- Abnormal urination
- Unusual sweating
- Nausea and vomiting
- Shortness of breath
- Puffy eyes
- Loss of appetite
- High blood pressure
The Treatment of Chronic Kidney Disease:
A kidney transplantation is the only conventional treatment for this chronic kidney failure condition. However, many patients lose their lives due to the paucity of organs. Those who get the transplant are also prone to the risk of immune rejection after this procedure. Apart from this, the patients may be given oral steroidal medicine to control inflammation. The critical patients need to be on dialysis regularly. But, these are supplementary treatments and transplantation is the only solution. The lifelong supplementary drugs complicate the body conditions over time. Hence, the medical fraternity is looking forward to finding a possible cure for this disease with stem cell therapy in India.
How Can Stem Cells Help in Curing Chronic Kidney Disease?
CKD leads to the dysfunction of cells and triggers the release of cytokines. They cause inflammation of the cells that ultimately damage the kidney. There is a rapid interposition of scar tissue due to which the infectious microorganisms cannot attack the injury. However, it also prevents the regeneration of renal tissue cells.
When stem cells are transplanted into a patient’s body, they reduce the creatinine levels. The mesenchymal stem cells differentiate into renal cells and migrate to the affected area. They regenerate the damaged renal tissues and activate the resident stem cells by sending auto-crine signals. In short, these cells provide a proper environment for regeneration of damaged cells by differentiating into renal cells.
Mesenchymal stem cell-based therapy has become a potential treatment for this disease due to its advantages. These cells are antiapoptic, immune modulating, anti-fibrosis, and anti-inflammatory. This treatment is also effective for maintaining or reducing the level of creatinine serum in the body of chronic kidney patient. But, most of these treatments are in the stage of clinical trials and studies.