Stargardt’s Disease is a form of macular dystrophy that begins early in life. Dr. Stargardt first described this condition in 1909 giving it its name. Stargardt disease is also called Stargardt macular dystrophy, juvenile macular degeneration, or fundus flavimaculatus. The disease causes progressive damage—or degeneration—of the macula, which is a small area in the center of the retina that is responsible for sharp, straight-ahead vision. Stargardt disease is one of several genetic disorders that cause macular degeneration. Experts estimate that 1 in 8-10 thousand people have Stargardt disease. It is one of the most common forms of a juvenile macular degeneration. Stargardt’s disease may occur in one of every 20,000 children over the age 6 and is usually diagnosed before the age of 20. Boys and girls are equally affected by this condition. Stargardt’s is usually a recessively inherited condition requiring the person to receive a gene from each parent to cause the disease. However, there have been a number of cases identified as dominant inheritance, requiring only one gene from either parent. Recently researchers have identified the gene, ABCR, now called abca4, which causes Stargardt’s Disease.
Additionally, our best color vision resides in the macula. Thus, damage to the macula results in loss of visual acuity or sharpness of vision decreased color vision and small blind spots. Diagnosis: Early in the disease, the macula may appear normal which may slow the initial diagnosis of Stargardt’s. Children may be misdiagnosed with a psychological vision loss given as the diagnosis. In time, characteristic changes occur in the retinas that help facilitate diagnosis. Fluorescein angiography is a test in which a dye is injected into the arm and the flow of this dye as it enters the eye is studied. The damaged retina sits above a layer called the choroids which is rich in blood vessels that supply nutrients to the retina. During angiography in a patient with Stargardt’s, the damage to the retina blocks the flow of light from the choroids causing a “dark choroid” and this may be used to help diagnosis. Causes: The retina contains light-sensing cells called photoreceptors. There are two types of photoreceptors: rods and cones. Together, rod and cones detect light and convert it into electrical signals, which are then “seen” by the brain. Rods are found in the outer retina and help us see in dim and dark lighting. Cones are found in the macula and help us see fine visual detail and color. Both cones and rods die away in Stargardt disease, but for unclear reasons, cones are more strongly affected in most cases.
You may have heard about the importance of vitamin A-rich foods in maintaining healthy vision. That’s because vitamin A is needed to make key light-sensitive molecules inside photoreceptors. Unfortunately, this manufacturing process can lead to harmful vitamin A byproducts—which turn out to play a key role in Stargardt disease. Stem Cells for Stargardt’s Disease – ACT has launched a Phase I/II clinical trial of transplanted retinal pigment epithelial (RPE) cells for the treatment of Stargardt disease. The RPE cells are derived from human stem cells. RPE is the first cells affected in people with Stargardt disease. They play a critical role in maintaining the health and function of photoreceptors. The primary goal of the study is to demonstrate safety and tolerability. The results of this study provide the first evidence of the medium-term to long-term safety, graft survival, and possible biological activity of pluripotent stem cell progeny in individuals with any disease.
Our results suggest that Mesenchymal stem cells could provide a potentially safe new source of cells for the treatment of various unmet medical disorders requiring tissue repair or replacement. Stem Cell Therapy in India (SCT) is the treatment of various disorders, non-serious to life-threatening, by using stem cells. These stem cells can be procured from a lot of different sources and used to treat more than 80 disorders, like Leukaemia, Thalassemia, Aplastic anemia, Sickle cell, and MDS, with potential to treat neuromuscular disorders, degenerative disorders and genetic disorders, for example, Autism, Cerebral Palsy, Muscular Dystrophy, etc. At present, there aren’t any effective conventional treatments for many of these disorders, but the stem cell center in India has been showing a lot of promising results in India and all over the world. This is possible due to the amazing and unique features of stem cells.
We at Stemcellcure can proudly say that we provide the best Stem Cells for Stargardt’s Disease in India. Our years of research, hard work and trials have helped us pioneer and achieve amazing results when needed. Your precious cells are processed using our proprietary technology to ensure they possess the best features required for treatment. The stem cells produced by Stemcellcure are completely safe, non-toxic and totally avoid of side effects with an excellent probability of homing and engraftment with parent cell, tissue or organ are fascinated by the prospect of utilizing the potential of stem cells to change the life of people. It is amazing that the remedy for any degenerative ailment is available from within the body. We have developed expertise & capabilities in collecting and separating stem cells from all the available biological materials. We firmly believe that stem cells in the future for prevention of age-related degeneration. A time will come when the body’s own cells will help in restoring youth and remaining healthy without any drugs.
Stem cell therapy may provide some good advantages in case of such eye related disorder:-
1. A stem cell has the property to regenerate retinal pigment epithelium cells, optic nerve and photoreceptor cells.
2. Donor’s derived stem cell has the property to repair defective/mutated cells via infusing internally.
3. Stop the further progression of this disease
3. So overall it may improve some vision back.