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  • Coronary Arterial Disease

    Coronary arterial disease or coronary heart disease is the most common type of heart disease and cause of heart attacks.

    What is Coronary Arterial Disease


    Coronary arterial disease (CAD) is a condition in which plaque builds up inside the coronary arteries that supply oxygen-rich blood to your heart muscle. Plaque is made up of fat, cholesterol, calcium, fibrous tissue, and other substances in the blood. Over time, plaque can harden and narrow the arteries. This limits the flow of oxygen-rich blood to your organs and other parts of your body. The patients with coronary arterial disease also experience angina.

    Coronary arterial disease (PAD) causing an inadequate oxygen supply to the heart. Mainly the risk factors of coronary vascular disease are nicotine use, diabetes mellitus, hypertension and hypercholesterolemia.

    Don't worry. We are here to help you to recover soon.

    Introduction:


    Currently available surgical or endovascular revascularization like angioplasty and coronary artery bypass graft (CABG) are the main treatments for coronary arterial disease and myocardial infarction. Coronary artery disease involves not only the blockage of major arteries, but also the death of small blood vessels or capillaries and heart muscle. But the stem cells transplant with angioplasty induces the neo-vascularization and also reduces frequency of angina episodes.

    Transplantation of Bone Marrow Stem Cells into the infarct-related coronary artery via an angioplasty (by using with balloon catheter) provides neoangiogenesis (new vessel formation) in ischemic coronary artery. Bone Marrow Mononuclear cells (BM-MNC or Bone Marrow stem cells concentrate) is more useful in coronary arterial disease to get more re-vascularization because it contains all needed regenerative cells and also containing angiogenic growth factors such as vascular endothelial growth factor (VEGF) which improves endothelium-dependent vasodilation in patients with coronary arterial disease.

    Coronary arterial disease or coronary heart disease is the most common type of heart disease and cause of heart attacks.

    Scientific Papers


    1. Wang et al. 2010 (Cardiology). Intracoronary Autologous CD34+ Stem Cell Therapy for intractable Angina.

    2. Klein et al. 2004 (The Heart Surgery Forum). Autologous Bone Marrow´┐ŻDerived Stem Cell Therapy in Combination with TMLR.
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