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  • Stem cell supplement

    A nutritional supplement could stimulate the production of stem cells integral for repairing the body.

    Stem cell supplement/stem kine


    Stem cells are the body's natural healing mechanism. If a person is injured bad enough, either internally or externally, the body recruits stem cells from the bone marrow into the bloodstream and they mobilize to the point of injury to begin the healing process. There is a body of knowledge that demonstrates a positive correlation between the number of these circulating stem cells and health and regenerative capabilities.

    Dr. Neil Riordan, a leading stem cell researcher, hypothesized that certain food substances could trigger chemical signals in the body that would release stem cells from the bone marrow into circulation. Through his extensive knowledgebase and collaborative network of stem cell scientists, Dr. Riordan applied scientific methods to identify natural substances that would trigger such stem cell recruitment, leading to the development of Stem-Kine.

    Product Effectiveness


    To date, there has been no nutritional supplement proven to be more effective than Stem-Kine at mobilizing stem cells. The following results are based on multiple 2-week in vivo clinical trials and were validated in peer-reviewed publications:

    Stem Cell Type Max. Increase over Control Day at which peak occurred Increase over control at end of trial period
    Endothelial Progenitor Cells 100% 14 days 100%
    CD133+ Stem Cells 90% 7 days 200%
    CD 34+ Stem Cells 53% 2 days 10%
    Hematopoietic Colony Forming Stem Cells 45% 2 days 17%

    1. 100% increase in endothelial progenitor cells (EPC's), peaking at the end of the two week clinical trial period
    2. 90% increase in CD133+ stem cells, peaking at 7 days, with 20% increase over control at the end of the two week clinical trial period.
    3. 53% increase in CD34+ stem cells, peaking at 2 days, with 10% increase over control at the end of the two week clinical trial period.
    4. 40%-50% increase in hematopoietic colony forming stem cells, peaking at 2 days, with 15-20% increase over control at the end of the two week clinical trial period.

    Validation by Stem Cell Experts


    Results of Stem-Kine studies were validated in peer-reviewed publications co-authored by the following stem cell experts from independent universities including University of Utah - Salt Lake City, Indiana University, and University of California - San Diego.

    Proprietary Formula


    Stem-Kine is a proprietary blend of natural extracts and fermented products including Lactobacillus fermentum, goji berry, green tea, astralagus root, beta 1,3 glucan, antioxidant ellagic acid and vitamin D3. It is administered orally through capsule form.

    it is fact - the more healthy stem cells we have circulating in our bloodstream, the healthier and stronger we are to fight off disease and the aging process.

    Importance of Circulating Stem Cells:


    The following are examples of studies from leading journals that show a direct, positive correlation between the number of circulating stem cell and health and regenerative capabilities:

    Subject Finding Source
    Stroke
    Following a stroke, individuals with a higher content of circulating stem cells recover better than individuals with fewer circulating stem cells.
    Journal of Neurology, 2007
    Smoking
    Smokers have impaired circulating stem cells, which increase with cessation and decrease with resumption of smoking.
    Arteriosclerosis, Thrombosis, and Vascular Biology, 2004
    Vascular Health
    Circulating stem cells correlate with vascular health and cardiac risk factors.
    New England Journal of Medicine, 2003
    Injury Injured tissue mobilizes or "calls in" stem cells. Circulation, 2001
    Cardiac Regeneration Increasing the number of circulating stem cells with G-CSF leads to a therapeutic effect in cardiac regeneration. American Journal of Cardiology, 2007
    Alzheimer's Disease
    Individuals with Alzheimer's have reduced levels of circulating stem cells and a correlation exists between the decreased number of circulating stem cells and the severity of the disease.
    Neurology, 2009
    Migraine Headaches
    Patients with migraine headaches have decreased circulating stem cells.
    Neurology, 2008
    Erectile Dysfunction
    Erectile and endothelial function correlate with circulating endothelial progenitor cell levels.
    Journal of Sexual Medicine, 2009

    Natural Stem Cell Supplements - Age Proof Your Whole Body

    Executive Summaries of Peer Reviewed Publications


    1) Circulating endothelial progenitor cells: a new approach to anti-aging medicine?

    Mikirova et al. Circulating endothelial progenitor cells: a new approach to anti-aging medicine? Journal of Translational Medicine 2009, 7:106.

    This paper discusses endothelial dysfunction as a potential cause for numerous age-related degenerative conditions. Endothelial precursor cells (EPCs) provide damaged or senescent blood vessels a constant source of replenishment. Evidence is provided regarding the biology of EPCs in a variety of pathologies, indicating that EPCs are an endogenous repair mechanism for the body.

    Varying methods and controlling factors for EPC mobilization are discussed; including preliminary research on Stem-Kine, which provides a supplemental-based method for inducing stem cell mobilization. Co-authors of the publication include individuals from major universities and organizations, including Indiana University, University of California, San Diego, and University of Utah, Salt Lake City.

    Through an independent clinical trial, it was shown that Stem-Kine supplementation administered over a 2 week period (2 pills a day, twice daily) resulted in a 100% increase from baseline of circulating endothelial progenitor cells by the end of the 2 week period.

    2) Nutraceutical Augmentation of Circulating Endothelial Progenitor Cells and Hematopoietic Stem Cells in Human Subjects

    This research suggests that Stem-Kine, a commercially-available supplement, can increase the blood circulation of hematopoietic stem cells, which can give rise to all blood cells, and endothelial progenitor cells, which repair damage to blood vessels.

    In this trial, Stem-Kine was administered twice daily to 18 healthy volunteers for a period of 14 days, where peripheral blood was assessed on days 0, 1, 2, 7, and 14 for cells expressing hematopoietic stem cell markers. Results indicated significant increases in cells expressing CD133 and CD34 stem cell markers. Additionally, Stem-Kine supplementation increased cells expressing the EPC phenotype. Furthermore, significant increases in colony formation were observed from blood extracted on days 1 and 2. This means that the cells expressing the EPC phenotype were not only increased, but also capable of forming CFU-E (colony forming unit endothelium) generating activity.

    The investigation further discusses other nutritional supplements, noting either a lack of data or limited results over a short period of time. To the author's knowledge, this was the first study showing data of potential clinical significance using a nutritional supplement-based approach.

    A nutritional supplement could stimulate the production of stem cells integral for repairing the body.

    Appendix A: Scientific Findings on Circulating Stem Cells


    Finding: Following a stroke, individuals with a higher content of circulating stem cells recover better than individuals with fewer circulating stem cells.

    In a study from the University Hospital Pasteur, 25 patients who incurred a stroke were divided into 2 groups. The first (left side in graph) had a higher number of circulating stem cells after the stroke, the second had a lower number (right side in graph). On the y-axis is severity of the stroke's effects. One and three months after the stroke, the patients with higher amounts of circulating stem cells had a more profound neurological recovery as compared to patients who had lower stem cell counts.

    Reference: Dunac et al. Neurological and functional recovery in human stroke are associated with peripheral blood CD34+ cell mobilization. J Neurol. 2007 Mar;254(3):327-32.
    stem cell supplement and stem cell therapy
    Finding: Smokers have impaired circulating stem cells, which increase with cessation and decrease with resumption of smoking.


    The effects of chronic smoking and subsequent termination were examined on circulating EPC levels. Participants included 14 nonsmokers and 15 smokers; all of the smokers quit smoking. It was found that circulating PCs and EPCs increased promptly after cessation and decreased again following resumption of smoking (resembling a level similar to pre-termination). Recovery of EPCs was found to be greater in light smokers than in heavy smokers. The graph on the left illustrates the levels of circulating progenitor cells corresponding to various time frames following smoking cessation and resumption.

    Reference: Kondo et al. Smoking cessation rapidly increases circulating progenitor cells in peripheral blood in chronic smokers. Arterioscler Thromb Vasc Biol. 2004 Aug;24(8):1442-7. J Neurol. 2007 Mar;254(3):327-32.
    stem cell supplement and stem cell therapy
    Finding: Circulating stem cells correlate with vascular health and cardiac risk factors.


    In a study published in the New England Journal of Medicine, it was hypothesized that EPCs had a significant role in continuing endothelial repair, where decreased or damaged mobilization would contribute to endothelial dysfunction and cardiovascular disease progression. They measured the amount of circulating EPCs that were able to form colonies (colony-forming units) in blood samples of 45 men who had differing degrees of cardiac risk factors but had never suffered cardiovascular disease. It was shown that a strong correlation existed between the number of circulating EPCs and the subject's Framingham Risk Score - a measure of risk for cardiovascular disease (see graph to the right). Significant correlations also existed between the amount of progenitor cells and the participant's endothelial function; levels of circulating EPCs were actually a better predictor of vascular reactivity than the existence or nonexistence of cardiac risk factors.

    Reference: Hill et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med. 2003 Feb 13;348(7):593-600.
    stem cell supplement and stem cell therapy
    Finding: Circulating stem cells correlate with vascular health and cardiac risk factors.

    FDA Disclaimer:


    Stem-Kine is a food supplement only. Statements in this document have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent diseases.
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