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  • Muscular Dystrophy

    Muscular Dystrophy is a hereditary condition marked by progressive weakening and wasting of the muscles.

    What is muscular dystrophy(MD)


    Duchenne muscular dystrophy (DMD) is general term for a number of hereditary, progressive degenerative disorders affecting skeletal muscles, and often other organ systems whose manifestation is augmented by inflammatory mechanisms. Given this modality appears to function via suppression of underlying inflammation.
    There are many different types of muscular dystrophy : -

    1.Becker muscular dystrophy
    2.Duchenne muscular dystrophy
    3.Emery-Dreifuss muscular dystrophy
    4.Facioscapulohumeral muscular dystrophy
    5.Limb-girdle muscular dystrophy
    6.Myotonia congenita
    7.Myotonic dystrophy

    Don't worry. We are here to help you to recover soon.

    Introduction:


    There is no cure for Muscular Dystrophy but stem cell therapy mainly focuses on the inflammatory response in Muscular Dystrophy as a target for mesenchymal stem cell (MSC) therapy. In contrast to other cell based therapies attempted in DMD, Mesenchymal Stem Cells have the advantages to treat Muscular Dystrophy:-

    a) ability to fuse with and genetically complement dystrophic muscle to regenerate and repair the dystrophic muscle

    b) produce anti-inflammatory activities to stop the inflammation in MD

    c) produce trophic factors that may augment activity of endogenous repair cells.


    Muscular Dystrophy Rehabilitation:


    Rehabilitation is the part of stem cell therapy. Muscular Dystrophy patients should have some kind of rehabilitation to help maximize their potential and to help teach techniques which make everyday life easier. Rehabilitation including physiotherapy provides enhanced environment to make stem cell more functional by helping the cell migrating and proliferation fast.

    Key Points:-

    Physical therapy may improve your ability to perform daily activities and make you feel better. Occupational therapy may help you perform daily activities more easily-especially those involving your hands and arms, such as grooming, dressing, and eating. Assistive devices may be used to help you perform daily tasks.

    Muscular Dystrophy is a hereditary condition marked by progressive weakening and wasting of the muscles.

    Scientific Papers


    1. Thomas et al. 2009 (Cell Immunology). Mesenchymal Stem Cells as Anti-inflammatories: Implications for Treatment of Duchenne Muscular Dystrophy.

    2. Helen et al. 2008 (The New England Journal of Medicine). Cell Therapy for Muscular Dystrophy.
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